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サルコイドーシスについて

This page contains general information about sarcoidosis – it is a good place to start if you are new to the condition. For more in depth information on specific types of sarcoidosis (e.g. affecting lungs, eyes, skin etc.) please use the menu above.

Every case of sarcoidosis is unique; you should always consult your doctor about your treatment plan. The information below is based on best practice and evidence but should not be taken as a substitute for medical advice.

このページの情報はサルコイドーシス専門医の助けを借りて編集されています Dr R. Coker, Respiratory Medicine, Hammersmith Hospital, London and K.ベックマン博士 & J.ギャロウェイ博士、リウマチ、キングスカレッジ病院、ロンドン。

サルコイドーシスとは何ですか?

Sarcoidosis is a condition where lumps called granulomas develop at different sites within the body. Granulomas are made up of clusters of cells involved in inflammation. If many granulomas form in an organ, they can prevent that organ from working properly.

Sarcoidosis can affect many different parts of the body. It often affects the lungs but can also affect the skin, eyes, joints, nervous system, heart and other parts of the body.

Please read more information on different types of sarcoidosis by selecting the relevant page from the drop-down menu under ‘情報’ on the menu bar above.

サルコイドーシスを発症するのは誰?

サルコイドーシスは他の何かと誤診されることが多く、何人の人がその状態で暮らしているかについて意見の相違があります。しかし、サルコイドーシスはまれです。ほとんどの専門家は、イギリスでは1万人に1人の割合でサルコイドーシスがあることに同意しています。英国では毎年約3,000人から4,000人がサルコイドーシスと診断されています。

Sarcoidosis is prevalent in both men and women as well as all major ethnicities. There has been some research suggesting that it is slightly more prevalent in women than men. Our own research agrees with that – in SarcoidosisUK’s online community survey, 69% of respondents were female and 31% were male (7,002 participants).

サルコイドーシスはどの年齢でも起こりますが、一般的に30代から40代の成人に発症します。私たちのコミュニティ調査では、4,833人が自分の年齢を教えてくれました。このデータは、サルコイドーシスがすべての年齢層で蔓延していることを示しています - 症例の80%は37〜65歳です。(報告された年齢は診断時の年齢ではなく、報告時に示された年齢です)

よく引用される アメリカの研究 アフリカとスカンジナビアの遺産の人々は、遺伝的要素を意味している状態と契約するより大きなチャンスを持っていると言います。

What Causes Sarcoidosis?

The exact cause of sarcoidosis is not known. It probably involves a precise combination of genetic and environmental factors. The condition does run in some families. So far, a single factor causing sarcoidosis has not been identified.

サルコイドーシスUKは、原因の究明と治療法の発見のために医学研究に資金を提供しています。もっと読む サルコイドーシスUK Research.

A number of websites claim to understand the causes of sarcoidosis and will sell you a cure. Please always consult your doctor before considering an alternative therapy.

What Parts of the Body are Affected?

サルコイドーシスは、体のほとんどすべての部分に影響を及ぼします。胸部の肺とリンパ腺が最も一般的に関与しており、サルコイドーシス患者10人中9人が罹患しています。

一般的に関与している可能性のある体の他の部分は、体の他の部分にある皮膚、眼、およびリンパ腺です。

関節、筋肉、骨は5人に1人の割合で関与しています。神経や神経系は、20人に1人の割合で関与しています。心臓は50人に約1人の患者が関与しています。

サルコイドーシスの症状は何ですか?

サルコイドーシスの症状は、体のどの部分が罹患しているかによって異なります。それらは含むことができます:

  • 息切れ
  • 赤や痛みを伴う目
  • 腫れた腺
  • 皮膚の発疹
  • 関節、筋肉または骨の痛み
  • 顔、腕、脚のしびれや脱力

Patients with sarcoidosis may feel tired and lethargic (fatigued), lose weight or suffer with fevers and night sweats. 

時々、サルコイドーシスの症状は突然始まり、長続きしません。他の患者では、症状が徐々に発生し、長年続くことがあります。

Some people don’t have any symptoms at all and are told they have sarcoidosis after having a routine chest X-ray or other investigations.

サルコイドーシスについてもっと読む…

サルコイドーシスの病因と歴史

「サルコイドーシス」という言葉はギリシャ語から来ています 石棺 接尾辞「肉」を意味する - (e)イド meaning “resembles”, and - シス, a common suffix in Greek meaning “condition”. Therefore the whole word can be translated as something like “a condition that resembles flesh”. 

Sarcoidosis was first described in 1877 by English dermatologist Dr. Jonathan Hutchinson as “a condition causing red, raised rashes on the face, arms and hands”. Between 1909 and 1910 uveitis in sarcoidosis was first described. By 1915 it was first emphasised, by Dr. Schaumann, that it was a systemic condition (affecting the whole body).

続きを読む: Definition and history of sarcoidosis (Sharma, 2005). 

Definition of Sarcoidosis

Sarcoidosis is famously hard to define. This is partly because of how complicated the condition can be and partly because of the lack of any known cause. SarcoidosisUK’s definition is at the top of this page. Below are some other definitions to help you more easily understand and explain sarcoidosis.

Common definition (use with friends/family/employer):

Sarcoidosis is a condition that can affect any part of the body, most often the lungs. Clumps of cells called ‘granulomas’ stop the affected organ(s) working properly. There is no known cause or cure. It affects everyone differently and the symptoms depend on the organ(s) affected. In most cases, sarcoidosis can be managed by medication and goes away after a few months or years. In the long-term it can lead to serious organ damage.

Clinical definition (use with healthcare professionals):

Sarcoidosis is a systemic granulomatous disease that primarily affects the lung and lymphatic systems of the body. A diagnosis of the disorder usually requires the demonstration of typical lesions in more than one organ system and exclusion of other disorders known to cause granulomatous disease. The appropriate therapy for the disorder also has not been well defined for all patients. Most importantly, the cause of the disorder is still unknown.

(ATS, ERS and WASOG Joint Statement on Sarcoidosis, 1999)

Official definition (for legal/official purposes):

Sarcoidosis is a multisystem disorder of unknown cause characterized by the formation of immune granulomas in involved organs. The lung and the lymphatic system are predominantly affected, but virtually every organ may be involved. Other severe manifestations result from cardiac, neurological, ocular, kidney or laryngeal localizations.

(World Health Organisation, International Classification of Diseases, 11th Revision (ICD-11), June 2018)

リーフレットをダウンロードしてください。

SarcoidosisUK Leaflet – Sarcoidosis Overview

サルコイドーシスはどのように診断されますか?

Sarcoidosis is difficult to diagnose because the symptoms often resemble other diseases. There is no single or specific test to diagnose sarcoidosis. 

A detailed history and examination by your doctor is the most important first step in diagnosing sarcoidosis. They will determine which parts of your body may be affected.

Blood tests Your doctor may arrange blood tests to look for signs of inflammation, to check your kidney and liver function, and your calcium levels. They may also check a marker in your blood called angiotensin-converting enzyme (ACE), which is sometimes raised in patients with sarcoidosis.

If your doctor suspects your lungs may be affected, they will usually arrange a chest X-ray and breathing tests (spirometry).

スキャン Your doctor may also arrange imaging scans (CT scan or PET CT scan) to look for other parts of your body that may be affected but might not be causing you any symptoms. The scans will look for inflammation (granulomas).

生検 In order to help make a definite diagnosis of sarcoidosis a sample of tissue (a biopsy) is taken from one of the areas of inflammation (granuloma) using a bronchoscopy.

As sarcoidosis can affect many different parts of the body, your doctor may ask other specialists (who specialise in the part of your body affected by sarcoidosis) to look after you as well. SarcoidosisUK has further information on all the different types of sarcoidosis, please use the menu above to find the best information for you.

見通し

Sarcoidosis gets better without treatment in most patients (around 60%). In others, the condition persists and may require some treatment.

In the minority of patients that develop a more serious form of the disease, more aggressive and prolonged treatment is sometimes required.

A much smaller proportion of patients present with life-threatening symptoms, particularly in those with pulmonary fibrosis (lung scarring) or heart or neurological involvement.

サルコイドーシスの治療

There is currently no known cure for sarcoidosis.

Treatment is often necessary for patients whose sarcoidosis is causing severe symptoms or is preventing the affected organ(s) from functioning normally. Sometimes simple painkillers (paracetamol or non-steroidal anti-inflammatory such as ibuprofen) may help to ease the symptoms.

The drugs used to treat sarcoidosis do so by reducing inflammation in the body. These are known as immunosuppressants. The most commonly used drugs are corticosteroids. These can be taken as a tablet (prednisolone) or given at a higher dose via a vein (methylprednisone). Treatment with corticosteroids is often required for at least 6 to 24 months.

Sometimes corticosteroids may not be completely effective, or cause side effects. Other immunosuppressants may be used, either alone or in combination, to help reduce the steroid dose. These medications include Methotrexate, Azathioprine and Mycophenolate.

サルコイドーシスの慢性の症例は通常薬物によって制御することができます。まれに、酸素や肺の移植が必要な患者もいます。めったにありませんが、心臓の損傷または心臓の近くでのペースメーカーまたはその他の治療が必要になることがあります。目や皮膚がサルコイドーシスに罹患している場合は、他の治療法も必要になるかもしれません。特定の種類のサルコイドーシスの治療に関する詳細については、上のメニューを使用して特定のページを確認してください。

健康的な生活

Sometimes patients’ symptoms may suddenly get worse (‘flare-up’). This may be triggered by stress, illness or nothing recognisable. Make sure you eat healthily, pace yourself, talk to friends and family and recognise mental health problems.

お願いします サルコイドーシスUK or your GP for further professional support.

Page last updated: August 2019. Next review: August 2021.

SarcoidosisUKからの関連コンテンツ:

サルコイドーシスと肺

肺サルコイドーシスはありますか?サルコイドーシスは肺に影響を与えますか詳しくはここをクリックしてください。

サルコイドーシスと皮膚

皮膚サルコイドーシスはありますか?結節性紅斑、狼瘡、および病変が一般的な徴候です。続きを読む。

サルコイドーシスと眼

サルコイドーシス患者の約半分が眼の症状を経験します。サルコイドーシスがどのように眼に影響を与えるかについてもっと読んでください。

サルコイドーシスと関節、筋肉と骨

サルコイドーシスは関節、筋肉、骨に影響を与えますか?詳細については、下をクリックしてください。

サルコイドーシスと神経系

サルコイドーシスは神経系に影響を及ぼします(神経サルコイドーシス)。詳しくは下をクリックしてください。

サルコイドーシスと心

サルコイドーシスは、肺のサルコイドーシスの結果として心臓に直接および間接的に影響を及ぼします。詳細はこちら

サルコイドーシスと疲労

あなたは疲労を経験しますか?サルコイドーシスと疲労についての症状、治療法そしてより多くの情報を見つけてください。

コンサルタントディレクトリ

あなたはコンサルタントを見つけたいですか?お近くのサルコイドーシス専門医または診療所を見つけるために私達のディレクトリを使用してください。

サルコイドーシスUKのサポート

どうすればあなたをサポートできますか?ナースヘルプライン、サポートグループ、オンラインサポートの詳細をご覧ください。

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