020 3389 7221 info@sarcoidosisuk.org
Pasirinkite Puslapis

APIE SARCOIDOSĄ

This page contains general information about sarcoidosis – it is a good place to start if you are new to the condition. For more in depth information on specific types of sarcoidosis (e.g. affecting lungs, eyes, skin etc.) please use the menu above.

Every case of sarcoidosis is unique; you should always consult your doctor about your treatment plan. The information below is based on best practice and evidence but should not be taken as a substitute for medical advice.

Šiame puslapyje pateikta informacija buvo surinkta naudojant sarkoidozės specialistus Dr R. Coker, Respiratory Medicine, Hammersmith Hospital, London and Dr. K. BechmanDr J. GallowayReumatologija, Kings College Hospital, Londonas.

Kas yra sarkoidozė?

Sarcoidosis is a condition where lumps called granulomas develop at different sites within the body. Granulomas are made up of clusters of cells involved in inflammation. If many granulomas form in an organ, they can prevent that organ from working properly.

Sarcoidosis can affect many different parts of the body. It often affects the lungs but can also affect the skin, eyes, joints, nervous system, heart and other parts of the body.

Please read more information on different types of sarcoidosis by selecting the relevant page from the drop-down menu under ‘Informacija’ on the menu bar above.

Kas vysto sarkoidozę?

Sarkoidozė dažnai klaidingai diagnozuojama kaip kažkas, ir yra nesutarimų, kiek žmonių gyvena su sąlyga. Tačiau mes žinome, kad sarkoidozė yra reta. Dauguma specialistų sutinka, kad maždaug 1 iš 10 000 žmonių turi sarkoidozę JK. Kiekvienais metais Jungtinėje Karalystėje diagnozuojama 3–4 000 žmonių, sergančių sarkoidoze.

Sarcoidosis is prevalent in both men and women as well as all major ethnicities. There has been some research suggesting that it is slightly more prevalent in women than men. Our own research agrees with that – in SarcoidosisUK’s online community survey, 69% of respondents were female and 31% were male (7,002 participants).

Sarkoidozė gali pasireikšti bet kokiame amžiuje, tačiau dažniausiai pasireiškia suaugusiesiems jų 30–40 metų amžiaus. 4 833 mūsų bendruomenės apklausos dalyviai nurodė savo amžių. Duomenys rodo, kad sarkoidozė yra paplitusi visose amžiaus grupėse - 80% atvejų yra tarp 37 ir 65 metų. Vidutinis vidutinis amžius buvo 50 metų.

Dažnai cituojama Amerikos moksliniai tyrimai sako, kad Afrikos ir Skandinavijos paveldo žmonės turi didesnę galimybę susitvarkyti su sąlyga, kad tai yra genetinis elementas.

What Causes Sarcoidosis?

The exact cause of sarcoidosis is not known. It probably involves a precise combination of genetic and environmental factors. The condition does run in some families. So far, a single factor causing sarcoidosis has not been identified.

SaroidoidozėUK imasi lyderio finansuojant medicininius tyrimus, kad nustatytų priežastis ir išgydytų. Skaitykite daugiau apie SarkoidozėUK tyrimai.

A number of websites claim to understand the causes of sarcoidosis and will sell you a cure. Please always consult your doctor before considering an alternative therapy.

What Parts of the Body are Affected?

Sarkoidozė gali paveikti beveik bet kurią kūno dalį. Dažniausiai dalyvauja plaučių ir limfmazgių krūtinės ląstos, pasireiškiančios 9 iš 10 pacientų, sergančių sarkoidoze.

Kitos kūno dalys, kurios gali būti dažniausiai susijusios, yra oda, akys ir limfinės liaukos kitoje kūno dalyje.

Sąnariai, raumenys ir kaulai dalyvauja 1 iš 5 pacientų. Nervai ir nervų sistema dalyvauja maždaug 1 iš 20 pacientų. Širdis dalyvauja maždaug 1 iš 50 pacientų.

Kokie yra sarkoidozės simptomai?

Sarkoidozės simptomai priklauso nuo kūno dalies. Jie gali apimti:

  • kosulys
  • jausmas kvėpuoja
  • raudonos arba skausmingos akys
  • patinusios liaukos
  • odos bėrimas
  • skausmas sąnariuose, raumenyse ar kauluose
  • veido, rankų, kojų tirpimas ar silpnumas

Patients with sarcoidosis may feel tired and lethargic (fatigued), lose weight or suffer with fevers and night sweats. 

Kartais sarkoidozės simptomai prasideda staiga, o ne ilgai. Kitiems pacientams simptomai gali išsivystyti palaipsniui ir trunka daugelį metų.

Some people don’t have any symptoms at all and are told they have sarcoidosis after having a routine chest X-ray or other investigations.

Skaityti daugiau apie sarkoidozę ...

Sarkoidozės etimologija ir istorija

Žodis „sarkoidozė“ kilęs iš graikų kalbos sarcο- reiškia „kūnas“, priesaga - (e) ido meaning “resembles”, and -sis, a common suffix in Greek meaning “condition”. Therefore the whole word can be translated as something like “a condition that resembles flesh”. 

Sarcoidosis was first described in 1877 by English dermatologist Dr. Jonathan Hutchinson as “a condition causing red, raised rashes on the face, arms and hands”. Between 1909 and 1910 uveitis in sarcoidosis was first described. By 1915 it was first emphasised, by Dr. Schaumann, that it was a systemic condition (affecting the whole body).

Skaityti daugiau: Definition and history of sarcoidosis (Sharma, 2005). 

Definition of Sarcoidosis

Sarcoidosis is famously hard to define. This is partly because of how complicated the condition can be and partly because of the lack of any known cause. SarcoidosisUK’s definition is at the top of this page. Below are some other definitions to help you more easily understand and explain sarcoidosis.

Common definition (use with friends/family/employer):

Sarcoidosis is a condition that can affect any part of the body, most often the lungs. Clumps of cells called ‘granulomas’ stop the affected organ(s) working properly. There is no known cause or cure. It affects everyone differently and the symptoms depend on the organ(s) affected. In most cases, sarcoidosis can be managed by medication and goes away after a few months or years. In the long-term it can lead to serious organ damage.

Clinical definition (use with healthcare professionals):

Sarcoidosis is a systemic granulomatous disease that primarily affects the lung and lymphatic systems of the body. A diagnosis of the disorder usually requires the demonstration of typical lesions in more than one organ system and exclusion of other disorders known to cause granulomatous disease. The appropriate therapy for the disorder also has not been well defined for all patients. Most importantly, the cause of the disorder is still unknown.

(ATS, ERS and WASOG Joint Statement on Sarcoidosis, 1999)

Official definition (for legal/official purposes):

Sarcoidosis is a multisystem disorder of unknown cause characterized by the formation of immune granulomas in involved organs. The lung and the lymphatic system are predominantly affected, but virtually every organ may be involved. Other severe manifestations result from cardiac, neurological, ocular, kidney or laryngeal localizations.

(World Health Organisation, International Classification of Diseases, 11th Revision (ICD-11), June 2018)

Kaip diagnozuojama sarkoidozė?

Sarcoidosis is difficult to diagnose because the symptoms often resemble other diseases. There is no single or specific test to diagnose sarcoidosis. 

A detailed history and examination by your doctor is the most important first step in diagnosing sarcoidosis. They will determine which parts of your body may be affected.

Blood tests Your doctor may arrange blood tests to look for signs of inflammation, to check your kidney and liver function, and your calcium levels. They may also check a marker in your blood called angiotensin-converting enzyme (ACE), which is sometimes raised in patients with sarcoidosis.

Plaučiai If your doctor suspects your lungs may be affected, they will usually arrange a chest X-ray and breathing tests (spirometry).

Nuskaito Your doctor may also arrange imaging scans (CT scan or PET CT scan) to look for other parts of your body that may be affected but might not be causing you any symptoms. The scans will look for inflammation (granulomas).

Biopsija In order to help make a definite diagnosis of sarcoidosis a sample of tissue (a biopsy) is taken from one of the areas of inflammation (granuloma) using a bronchoscopy.

As sarcoidosis can affect many different parts of the body, your doctor may ask other specialists (who specialise in the part of your body affected by sarcoidosis) to look after you as well. SarcoidosisUK has further information on all the different types of sarcoidosis, please use the menu above to find the best information for you.

„Outlook“

Sarcoidosis gets better without treatment in most patients (around 60%). In others, the condition persists and may require some treatment.

In the minority of patients that develop a more serious form of the disease, more aggressive and prolonged treatment is sometimes required.

A much smaller proportion of patients present with life-threatening symptoms, particularly in those with pulmonary fibrosis (lung scarring) or heart or neurological involvement.

Sarkoidozės gydymas

There is currently no known cure for sarcoidosis.

Treatment is often necessary for patients whose sarcoidosis is causing severe symptoms or is preventing the affected organ(s) from functioning normally. Sometimes simple painkillers (paracetamol or non-steroidal anti-inflammatory such as ibuprofen) may help to ease the symptoms.

The drugs used to treat sarcoidosis do so by reducing inflammation in the body. These are known as immunosuppressants. The most commonly used drugs are corticosteroids. These can be taken as a tablet (prednisolone) or given at a higher dose via a vein (methylprednisone). Treatment with corticosteroids is often required for at least 6 to 24 months.

Sometimes corticosteroids may not be completely effective, or cause side effects. Other immunosuppressants may be used, either alone or in combination, to help reduce the steroid dose. These medications include Methotrexate, Azathioprine and Mycophenolate.

Lėtinius sarkoidozės atvejus paprastai gali kontroliuoti vaistai. Retais atvejais kai kuriems pacientams reikia deguonies ir plaučių persodinimo. Lygiai taip pat retai širdies sužalojimas ar šalia jo gali reikėti širdies stimuliatoriaus ar kito gydymo. Kiti gydymo būdai taip pat gali būti reikalingi, kai akis ir odą veikia sarkoidozė. Jei norite gauti daugiau informacijos apie konkrečių sarkoidozės tipų gydymą, patikrinkite konkrečius puslapius, naudodami aukščiau esantį meniu.

Sveika gyvensena

Sometimes patients’ symptoms may suddenly get worse (‘flare-up’). This may be triggered by stress, illness or nothing recognisable. Make sure you eat healthily, pace yourself, talk to friends and family and recognise mental health problems.

Prašau susisiekite su SarcoidosisUK or your GP for further professional support.

Page last updated: August 2019. Next review: August 2021.

Susijęs turinys iš SarcoidosisUK:

Sarkoidozė ir plaučiai

Ar turite plaučių sarkoidozę? Ar sarkoidozė veikia plaučius. Jei norite sužinoti daugiau, spustelėkite čia.

Sarkoidozė ir oda

Ar turite odos sarkoidozę? Erythema Nodosum, Lupus Pernio ir pažeidimai yra dažni požymiai. Skaityti daugiau.

Sarkoidozė ir akis

Apie pusė sarkoidozės sergančių pacientų patiria akių simptomus. Sužinokite daugiau apie tai, kaip sarkoidozė gali paveikti akį.

Sarkoidozė ir sąnariai, raumenys ir kaulai

Ar sarkoidozė veikia jūsų sąnarius, raumenis ar kaulus? Jei norite rasti daugiau informacijos, spustelėkite žemiau.

Sarkoidozė ir nervų sistema

Sarkoidozė gali paveikti nervų sistemą (neurosarkoidozę). Jei norite daugiau sužinoti, spustelėkite toliau.

Sarkoidozė ir širdis

Sarkoidozė gali tiesiogiai ir netiesiogiai paveikti širdį dėl sarkoidozės plaučiuose. Daugiau informacijos rasite čia.

Saroidoidozė ir nuovargis

Ar patiriate nuovargį? Rasti simptomus, gydymą ir daugiau informacijos apie sarkoidozę ir nuovargį.

Konsultantų katalogas

Ar norite rasti konsultantą? Naudokite mūsų katalogą, kad surastumėte sarkoidozės specialistą ar kliniką šalia jūsų.

SarkoidozėUK parama

Kaip galime jus paremti? Sužinokite daugiau apie mūsų slaugytojo pagalbos liniją, palaikymo grupes ir internetinę pagalbą.

Pasidalinti